Study record
Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation
Lu H, Tang S, Xue C et al. · Int J Mol Sci · 2019
AnimalMOTS-c administeredEvidence tier C
What this study reported
In mice, serum MOTS-c decreased after cold stress. MOTS-c treatment was associated with better cold tolerance, less lipid trafficking to the liver, upregulated brown adipose thermogenic genes and more white fat browning, and ERK inhibition disturbed the effect on thermogenesis.
Limitations
Males only; group sizes and administration details not reported in the abstract; ERK mediation is described as possible.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Male mice exposed to cold stress |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | cold-exposed mice not given MOTS-c (implied); ERK inhibition |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c after cold stress; cold tolerance; brown adipose thermogenic gene expression; white fat browning; lipid trafficking to liver; ERK phosphorylation |
| Pathways measured | Thermogenesis / brown fat · MAPK signalling · Lipid metabolism |
| Research areas | Metabolic |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.