Study record
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome
Raijmakers RPH, Jansen AFM, Keijmel SP et al. · J Transl Med · 2019
Human obs.Related mitochondrial peptideEvidence tier B
What this study reported
Found decreased expression of the MDP-coding genes MT-RNR1 (MOTS-c) and MT-RNR2 (humanin) in monocytes from QFS, CFS and, to a lesser extent, Q fever seropositive controls compared with healthy controls. Humanin production was reported as decreased; MOTS-c peptide levels are not reported in the abstract.
Limitations
Small groups; MOTS-c assessed only via expression of its host gene MT-RNR1, not as peptide.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | human |
| System studied | Monocyte RNA sequencing in Q fever fatigue syndrome, chronic fatigue syndrome and controls |
| Population | patients with Q fever fatigue syndrome or chronic fatigue syndrome, Q fever seropositive controls and healthy controls |
| Design | Case-control transcriptome study |
| Sample size as reported | 40 (10 QFS, 10 CFS, 10 Q fever seropositive controls, 10 healthy controls) |
| Control group | age- and sex-matched healthy controls |
| Route (data field only) | Not reported |
| Endpoints measured | monocyte transcriptome; MT-RNR1 (MOTS-c) expression; MT-RNR2 (humanin) expression; humanin levels |
| Pathways measured | Inflammation |
| Research areas | Inflammation & immunity · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.