Study record
Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects
Ramanjaneya M, Jerobin J, Bettahi I et al. · Clin Endocrinol (Oxf) · 2019
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
In women with PCOS and controls, intralipid infusion increased plasma MOTS-c, and the subsequent insulin infusion blunted this rise (significantly only in PCOS before training). Exercise training did not change circulating MOTS-c in either group.
Limitations
Sample size not given in the abstract; ELISA-based measurement; women only.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Women with PCOS and healthy controls undergoing intralipid or saline infusion with a hyperinsulinaemic-euglycaemic clamp, before and after exercise training |
| Population | women with polycystic ovary syndrome and healthy controls |
| Design | Infusion and clamp study with exercise intervention; MOTS-c measured |
| Sample size as reported | Not reported |
| Control group | healthy controls; saline infusion |
| Route (data field only) | Not reported |
| Endpoints measured | plasma MOTS-c (ELISA); response to intralipid infusion; response to insulin clamp; change after exercise training |
| Pathways measured | Insulin & glucose handling · Lipid metabolism |
| Research areas | Metabolic · Reproductive · Exercise |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.