Study record
MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction
Lu H, Wei M, Zhai Y et al. · J Mol Med (Berl) · 2019
AnimalMOTS-c administeredEvidence tier C
What this study reported
In ovariectomized mice, MOTS-c treatment was associated with less weight gain and insulin resistance, more brown fat activation, and less fat accumulation and inflammatory infiltration in white adipose tissue. MOTS-c activated the AMPK pathway, and an AMPK pathway blocker attenuated its effect on adipocyte lipid metabolism.
Limitations
Females only in a single surgical menopause model; group sizes and administration details not reported in the abstract.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Ovariectomized female C57BL/6 mice as a model of postmenopausal metabolic dysfunction |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | ovariectomized mice not given MOTS-c (implied); AMPK pathway blocker |
| Route (data field only) | Not reported |
| Endpoints measured | body weight and fat mass; insulin resistance; brown fat activation; white adipose inflammation; serum and liver fatty acids; AMPK activation |
| Pathways measured | AMPK signalling · Thermogenesis / brown fat · Lipid metabolism · Inflammation · Insulin & glucose handling |
| Research areas | Metabolic · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.