Study record
[The underestimated coding potential of mitochondrial DNA]
Angers A, Ouimet P, Tsyvian-Dzyabko A et al. · Med Sci (Paris) · 2019
ReviewSeveralEvidence tier R
What this study reported
Reviewed mitochondrial-derived peptides encoded within mtDNA, describing MOTS-c as discovered in silico and reported to be involved in metabolism and insulin sensitivity.
Limitations
Broad review in which MOTS-c is one of several peptides covered.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | French-language review of the coding potential of mitochondrial DNA (humanin, SHLPs, MOTS-c, Gau) |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondrial-derived peptides; insulin sensitivity |
| Pathways measured | Insulin & glucose handling |
| Research areas | Mitochondrial biology · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.