Study record
Mitochondrial-Derived Peptides Exacerbate Senescence
Mendelsohn AR, Larrick JW · Rejuvenation Res · 2018
ReviewSeveralEvidence tier R
What this study reported
Reviewed reports that humanin and MOTS-c improve insulin sensitivity in mouse models and that both increased secretion of SASP cytokines in senescent cells. Speculated on combining MDP-based approaches with senolytics.
Limitations
Narrative review with speculative proposals; the senescence discussion rests largely on a single cell-culture study.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Review of mitochondrial-derived peptides (humanin, MOTS-c) and cellular senescence |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | senescence-associated secretory phenotype; insulin sensitivity; cytoprotection |
| Pathways measured | Inflammation · Insulin & glucose handling |
| Research areas | Aging · Inflammation & immunity |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.