Study record
Mitochondrial peptides modulate mitochondrial function during cellular senescence
Kim SJ, Mehta HH, Wan J et al. · Aging (Albany NY) · 2018
CellsSeveralEvidence tier D
What this study reported
In senescent primary human fibroblasts, measured increased mitochondrial number and respiration and elevated humanin and MOTS-c levels. Humanin and MOTS-c administration modestly increased mitochondrial respiration and selected SASP components in doxorubicin-induced senescent cells, partially via the JAK pathway.
Limitations
Single cell type in culture; effects described as modest; MOTS-c and humanin results are reported together in the abstract.
Study record
| Study model | Cell study (in vitro) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human |
| System studied | Primary human fibroblasts made senescent by replicative exhaustion, doxorubicin or hydrogen peroxide |
| Population | Not reported |
| Design | Cell culture experiments |
| Sample size as reported | Not reported |
| Control group | non-senescent fibroblasts; untreated senescent cells |
| Route (data field only) | in-culture |
| Endpoints measured | mitochondrial number; mitochondrial respiration; mtDNA methylation; humanin, MOTS-c, SHLP2 and SHLP6 levels; SASP components |
| Pathways measured | Inflammation · Other |
| Research areas | Aging · Mitochondrial biology |
| Evidence tier | D — Cell, tissue or analytical |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Cellular
- Sample size
- n/a
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.