Study record
MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA
Zhai D, Ye Z, Jiang Y et al. · Mol Immunol · 2017
AnimalMOTS-c administeredEvidence tier CAlso: Cell study (in vitro)
What this study reported
In MRSA-challenged mice, MOTS-c was associated with higher survival and lower bacterial load, lower pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and higher IL-10. In macrophages, MOTS-c was reported to enhance bactericidal capacity, inhibit MAPK phosphorylation and increase AhR and STAT3 expression.
Limitations
Single infection model with group sizes, sex and administration details not reported in the abstract; macrophage source not specified.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Mice challenged with methicillin-resistant Staphylococcus aureus (MRSA); macrophages |
| Population | Not reported |
| Design | Controlled animal experiment with macrophage experiments |
| Sample size as reported | Not reported |
| Control group | MRSA-challenged mice not given MOTS-c (implied) |
| Route (data field only) | Not reported |
| Endpoints measured | survival; bacterial load; serum cytokines (TNF-α, IL-6, IL-1β, IL-10); macrophage bactericidal capacity; MAPK phosphorylation; AhR and STAT3 expression |
| Pathways measured | Inflammation · MAPK signalling |
| Research areas | Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.