Study record
Mitochondrially derived peptides as novel regulators of metabolism
Kim SJ, Xiao J, Wan J et al. · J Physiol · 2017
ReviewSeveralEvidence tier R
What this study reported
Reviewed the basic biology of mitochondrially derived peptides, including humanin, MOTS-c and SHLP1-6. Summarised prior reports that MOTS-c decreased weight gain in mice on a high-fat diet.
Limitations
Narrative review spanning several peptides; MOTS-c content is based on mouse studies.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Review of mitochondrially derived peptides (humanin, MOTS-c, SHLP1-6) in metabolism |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | weight gain; visceral fat; insulin release |
| Pathways measured | Insulin & glucose handling |
| Research areas | Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.