Study record

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

Lee C, Kim KH, Cohen P · Free Radic Biol Med · 2016

ReviewSeveralEvidence tier R
PubMed 27216708doi:10.1016/j.freeradbiomed.2016.05.015Full text (PMC)Compare with another study

What this study reported

Reviewed the mitochondrial genetic origin of humanin and MOTS-c and described MOTS-c as targeting skeletal muscle and enhancing glucose metabolism in earlier studies. Discussed possible implications for obesity, diabetes, exercise and longevity research.

Limitations

Narrative review written early in the field, drawing largely on a single discovery study and mouse data.

Study record

Annotated fields for this study
Study modelReview
Substance studiedSeveralMore than one of these is central to the paper (common for reviews).
SpeciesNot reported
System studiedNarrative review of MOTS-c and mitochondrial-derived peptides in muscle and fat metabolism
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredglucose metabolism; skeletal muscle targeting; mitochondrial signalling
Pathways measuredInsulin & glucose handling · Lipid metabolism
Research areasMetabolic · Skeletal muscle · Mitochondrial biology
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Direct
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
n/a

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.