Study record
The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?
Fuku N, Pareja-Galeano H, Zempo H et al. · Aging Cell · 2015
ReviewMT-RNR1 / K14Q variantEvidence tier R
What this study reported
Proposed that the m.1382A>C polymorphism in the MOTS-c-encoding mtDNA, described as specific to Northeast Asian populations, may be among the mechanisms underlying the high longevity of Japanese people. The abstract presents this as a suggestion requiring more research.
Limitations
The abstract reports no data, sample or genotype-association results; the link between the variant and longevity is stated as a hypothesis.
Study record
| Study model | Review |
|---|---|
| Substance studied | MT-RNR1 / K14Q variantStudies of the m.1382A>C (K14Q) variant or other MT-RNR1 variation. |
| Species | Not reported |
| System studied | Hypothesis paper on the m.1382A>C polymorphism in the MOTS-c-encoding mtDNA region and longevity in Japanese people |
| Population | Not reported |
| Design | Commentary / hypothesis |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | m.1382A>C polymorphism; longevity |
| Pathways measured | Not reported |
| Research areas | Aging |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.